About 5 results found for searched term "E3 ligase Ligand 3" (0.135 seconds)
Cat.No. | Name | Target |
---|---|---|
M9833 | E3 ligase Ligand 3 | Ligand for E3 Ligase |
Thalidomide-O-COOH; Cereblon ligand 3 | ||
E3 ligase Ligand 3 (Thalidomide-O-COOH) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein, it connected to the ligand for protein by a linker to form PROTACs. | ||
M9836 | Pomalidomide-PEG4-C-COOH | E3 Ligase Ligand-Linker Conjugates |
E3 Ligase Ligand-Linker Conjugates 1 | ||
Pomalidomide-PEG4-C-COOH (E3 Ligase Ligand-Linker Conjugates 1) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker. | ||
M14866 | E3 ligase Ligand 8 | Ligand for E3 Ligase |
E3 ligase Ligand 8 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 8 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins. | ||
M22448 | Thalidomide-NH-PEG3-propionic acid | PROTAC |
Thalidomide-NH-PEG3-propionic acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology. | ||
M54696 | DGY-09-192 | PROTAC |
DGY-09-192 is a bivalent degrader that couples the pan-FGFR inhibitor BGJ398 to the CRL2VHL E3 ligase-recruiting ligand, which induces degradation of FGFR1/2 and largely avoids degradation of FGFR3/4.DGY-09-192 exhibits a nanomolar DC50 against both wild-type FGFR2 and several FGFR2 fusions. In addition, DGY-09-192 has antiproliferative activity in gastric and cholangiocarcinoma cells. |
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